Active Ingredients

Trifluoperazine – Effect, Application & Risks

Trifluoperazine

Trifluoperazine is a neuroleptic . Due to its chemical and pharmacological properties, it is assigned to the active substance class of phenothiazines . However, trifluoperazine is less common in Germany, Austria and Switzerland. It is not on the regular drug market here.

What is trifluoperazine?

Trifluoperazine belongs to the class of drugs known as neuroleptics. The drug is used in human medicine to treat numerous mental illnesses. The treatment is carried out by a psychiatrist .

Trifluoperazine is rarely used in German-speaking countries. The only preparation so far that contains trifluoperazine as the main active ingredient is Jatroneural®. However, this is not available on the regular pharmaceutical market in Germany, Austria and Switzerland.

From a chemical point of view, trifluoperazine is a piperazine-substituted derivative of phenothiazine. The effects are described in the literature as antiemetic. This means that the drug can suppress nausea and vomiting , which is typical for members of its drug class. In addition to psychiatric use, it can also be used to treat nausea. However, the dosage will have to be adjusted accordingly.

In addition to the antiemetic effect, there are also sedative and antiadrenergic effects. Processes are described as antiadrenergic, the effect of which is directed against the effect of adrenaline .

Pharmacological effect on body & organs

Chemically, trifluoperazine is a derivative of phenothiazine. The mechanism of action of the neuroleptic is therefore essentially the same as that of phenothiazine. However, the exact details are still unclear.

The central thiazine ring of trifluoperazine contains both nitrogen and sulfur. A benzene ring is also present. Due to its open side chain at R2, the active ingredient is one of the chlorpromazine types with rather mild antipsychotic effects. Trifluoperazine can therefore be described as a low-potency or medium-potency neuroleptic.

According to the findings of a study by the Institute for Medical Biochemistry and Molecular Biology, trifluoperazine is able to bind to the protein calmodulin . This can prevent channels from closing, which could make it possible to use it in cancer treatment . However, this method of use has not yet found its way into everyday treatment.

Medicinal Application & Use for Treatment & Prevention

The antipsychotic effects of trifluoperazine are described as mild to moderate. However, the preparation Jatroneural® is one of the strong-acting neuroleptics.

According to current treatment guidelines, there is an indication for a low dose in states of excitement, anxiety and tension. Furthermore, trifluoperazine is used to treat sleep disorders , psychoses , depression and schizophrenia . In these cases, the administered dose must be calculated high. Regular intake is also particularly important.

Due to the antiemetic effects of trifluoperazine, taking it to prevent nausea is also conceivable. For this purpose, the dosage must be kept particularly low.

Regardless of the specific area of ​​application, trifluoperazine is usually taken orally in the form of film-coated tablets. In exceptional cases, allocation by injection is also possible.

Risks & side effects

Taking trifluoperazine can lead to undesirable side effects . However, this is not mandatory. However, application safety is guaranteed. The intake must be avoided if an allergy to phenothiazines is known. Otherwise incalculable risks arise.

The most common side effects of trifluoperazine include restlessness , late or early dyskinesia , a general feeling of restlessness or malaise, lack of emotion, drive disorders or similar psychological changes. In addition, there is a risk of dependency.

Organic side effects include damage to the kidneys or liver . It is therefore usually contraindicated for people with damage to these organs.

The following symptoms may also occur after an overdose of trifluoperazine: coma , convulsions , tremor , hallucinations , visual disturbances or psychomotor agitation. In addition, in the event of an overdose, the occurrence of anticholinergic effects is possible.

Lisa Newlon
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Hello! I am Lisa Newlon, and I am a medical writer and researcher with over 10 years of experience in the healthcare industry. I have a Master’s degree in Medicine, and my deep understanding of medical terminology, practices, and procedures has made me a trusted source of information in the medical world.