Active Ingredients

Tebipenem – Effect, Application & Risks

Tebipenem

Tebipenem is a medicinal substance that belongs to the group of carbapenems . Tebipenem is a so-called beta-lactam antibiotic that goes back to penicillin . It is used to fight infectious diseases caused by bacteria .

What is tebipenem?

Tebipenem is an antibiotic that is administered to treat infectious diseases. The chemical molecular formula of the substance (C 22 – H 31 – N 3 – O 6 – S 2) has a beta-lactam ring, which is why tebipenem belongs to the group of beta-lactam antibiotics and has a bactericidal effect.

The moral mass of the white to off-white substance is 497.63 g/mol. Because of its chemical and pharmacological properties, tebipenem is also classified as a carbapenem. Also part of this group of drugs are the closely related drugs ertapenem , imipenem , meropenem , and doripenem .

Tebipenem was specifically developed to counter existing antibiotic resistance. Despite positive experiences in some clinical studies, the active ingredient is currently only approved in Japan. The active ingredient is therefore not used in any preparations in Europe and the USA. The related drugs ertapenem, imipenem, meropenem and doripenem, on the other hand, are widely used in the European Union and the United States.

Pharmacological action

The pharmacological action of tebipenem is very similar to that of other carbapenems. The first successes can therefore be recorded quite early. Bacteria are quickly killed by the active ingredient by inhibiting cell migration renewal of the bacteria. Without the cell wall, bacteria cannot live because water can penetrate the interior of the cell and cause it to swell. The cell then ruptures, killing the bacterium.

Tebipenem is largely insensitive to the bacterial enzyme beta-lactasmase, which is typical for representatives of its active substance group. Bacteria need beta-lactasmase to prevent external attacks. The enzyme thus largely corresponds to the function of an antibody . Substances sensitive to beta-lactasmase are weakened in their effectiveness because they cannot attack the bacterium without losses. Because of its insensitivity to beta-lactasmase, tebipenem is therefore particularly effective.

However, it is necessary to maintain a continuously high level of the active ingredient in the body. A critical amount, from which the effectiveness reaches the optimum, must always be exceeded (time-dependent killing genetics). However, eukaryotic cells, which lack a cell wall, are insensitive to tebipenem and other beta-lactam antibiotics. The drug is mainly broken down renally (via the kidneys ).

Medical Application & Use

Tebipenem is given to fight infectious diseases that are caused by infectious bacteria. The drug was specifically developed to treat patients whose symptoms are caused by antibiotic-resistant bacteria as a replacement drug.

From a medical point of view, the field of application is therefore limited in comparison to other carbapenems, despite their comparatively high effectiveness. It should be used in particular when an infection has been acquired by resistant germs (e.g. in the hospital).

Tebipenem is therefore only the drug of choice in exceptional cases. In clinical studies, a particularly high effectiveness in ear infections was found, so that it is particularly suitable as an alternative to those carbapenems that are primarily prescribed for infections of the ear, nose and throat (ENT) area. In principle, however, due to its pharmacological effect, tebipenem should have the same areas of application as other representatives of beta-lactam antibiotics.

Tebipenem is also the first carbapenem whose prodrug form (pivalyl ester) is also suitable for oral use. A prodrug is a pharmacological substance that is either slightly active or completely inactive on its own and only becomes fully effective through metabolism in the body.

Risks & side effects

Tebipenem must not be used if there is a contraindication from a medical point of view (contraindication). This is the case, for example, if an intolerance ( allergy ) to tebipenem or other members of the beta-lactam group (e.g. penicillin) or related carbapenems (e.g. imipenem, meropenem and doripenem) is known.

Tebipenem should not be used even if there were complications or severe side effects from previous treatment with carbapenems . A contraindication is also given in the case of massive kidney damage , since the breakdown of the active substance occurs predominantly in the kidneys.

The most important undesirable side effects that can occur in connection with treatment include fungal infections , a general feeling of weakness and malaise, headache , fatigue , emotional upset and gastrointestinal disorders . Also conceivable are reactions of the skin, which can manifest themselves in itching , redness or the development of a rash .

In order to avoid interactions with other medications, the treating physicians should always be informed about all the preparations taken. Otherwise, there can be a reduction in effectiveness or an immense increase in side effects, which puts the therapy goals at considerable risk.

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Hello! I am Lisa Newlon, and I am a medical writer and researcher with over 10 years of experience in the healthcare industry. I have a Master’s degree in Medicine, and my deep understanding of medical terminology, practices, and procedures has made me a trusted source of information in the medical world.