Active Ingredients

Lymecycline – Effect, Application & Risks


Lymecycline is an antibiotic drug from the group of tetracyclines . A synonym for Lymecycline is Lymecyclinum .

What is lymecycline?

Lymecycline is a semi-synthetic tetracycline derivative. The drug is therefore one of the antibiotics and may only be taken on the prescription of a doctor. Tetracyclines are a group of antibiotic drugs whose original substance was produced from bacteria of the Streptomyces group .

Most tetracyclines and also lymecycline are derivatives of this substance that have been chemically modified. They usually have more favorable pharmacokinetics . This means that they are easier to apply and that absorption and distribution in the body are better. In addition, Lymecycline is better tolerated than the original form of tetracyclines.

Lymecycline is available in the form of capsules in drug stores. The active ingredient is mainly used to treat acne (acne vulgaris).

Pharmacological action

Lymecycline can inhibit the growth of acne bacteria in the skin ‘s sebaceous glands and hair follicles . Tetracyclines such as lymecycline have a bacteriostatic effect. This means that while they do not kill the bacteria that are present, they do prevent further growth.

Lymecycline binds to the so-called 30s subunit of the ribosomes in the bacterial cells. Ribosomes are cell organelles that are responsible, among other things, for the translation of RNA . By binding to the 30s subunits, the antibiotic agents modify the attachment of the aminoacyl-tRNA. The aminoacyl-tRNA cannot align properly due to the blockade of the subunit at the level of the 50s subunit. Thus, the peptidyl transferase reaction, which is important for reproduction, cannot be carried out correctly. The peptidyl transferase catalyzes the peptide bonds between the individual amino acids in the ribosome . So it ensures a chaining of the amino acids in the context of translation from theTransport RNAs are delivered. When this response is inhibited, the peptide chain breaks during protein synthesis . This inhibits the growth of the bacteria and stops them from multiplying.

In principle, tetracyclines are effective against both gram-positive and gram-negative bacteria. Bacterial genera without a cell wall are also sensitive to tetracyclines. Lymecycline is primarily effective against Propionibacterium acnes .

Medical Application & Use

Propionibacterium acnes is a gram-positive anaerobic bacterium that is part of the skin flora . The bacterium was formerly also known as Bacillus acnes or Corynebacterium acnes. It is involved in the formation of acne. The bacterium mainly lives in the sebum of hair follicles and here in particular in the follicles of the sebaceous glands.

It has the enzyme lipase and can therefore use components of the sebum to generate energy. This allows the bacterium to multiply quickly. When the sebum is processed, however, pro-inflammatory substances are produced. Chemotaxis leads to an accumulation of white blood cells in the tissue. When the immune cells die, pustules form that are filled with pus . These pustules are a main symptom of acne vulgaris.

Lymecycline inhibits the growth of acne bacteria in the sebaceous glands and hair follicles. This prevents the formation of pustules, cysts and inflammatory pus blisters .

Risks & side effects

The drug Lymecycline requires a prescription. It must not be prescribed if there is a known tetracycline hypersensitivity. The active ingredient can bind to calcium in the body and thus be stored in the bone and tooth-forming tissue. This can cause temporary growth disorders, which can also lead to malformation of the tooth enamel . Unsightly tooth discoloration can also occur. Tetracyclines such as lymecycline should therefore not be used in children under the age of eight and in pregnant women . Lymecycline should also not be taken while breastfeeding .

The drug must not be taken at the same time as oral retinoids . Among the retinoids are some drugs that are also used to treat acne.

Long exposure to the sun should be avoided while taking Lymecycline. Skin reddening can occur under direct sunlight or UV radiation . In addition, the effect of blood- thinning medication (anticoagulants) can be increased by taking lymecycline, so that bleeding can occur.

Patients taking antacids for stomach problems should not take these acid-binding drugs with lymecycline. The antacids interfere with the absorption of lymecycline into the blood .

Headaches , upper abdominal pain , and nausea may occur when taking Lymecycline . Uncommonly, affecting about 1 in 100 people, a rash will develop . Seizures , fatigue , vomiting , diarrhea , sore throat , dermatitis and muscle pain are also among the occasional side effects .

In rarer cases, serious, generalized allergic reactions can occur. The face, including the eyes and lips , may swell. The swelling may spread to the tongue and throat . This can result in life-threatening choking attacks. Furthermore, taking Lymecycline can lead to increased intracranial pressure , intestinal inflammation , inflammation of the tongue , blurred vision and fever .

If skin rashes and allergic symptoms appear, treatment with Lymecycline must be stopped immediately. For all other side effects, the doctor treating you should be informed as soon as possible.

Lisa Newlon
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Hello! I am Lisa Newlon, and I am a medical writer and researcher with over 10 years of experience in the healthcare industry. I have a Master’s degree in Medicine, and my deep understanding of medical terminology, practices, and procedures has made me a trusted source of information in the medical world.