Active Ingredients

Ketanserin – Effect, Application & Risks


Ketanserin refers to a substance that has properties that promote wound healing and lower blood pressure. The active ingredient is a serotonin antagonist and acts on different receptors in the human brain . However, ketanserin is not licensed as a drug for these purposes in the Federal Republic of Germany and is only used clinically in exceptional cases.

What is ketanserin?

Ketanserin is a special derivative that has been the subject of many studies and tests to obtain a detailed pharmacological analysis. Ketanserin is a very effective serotonin antagonist, which is an ingredient in numerous preparations.

The drug ketanserin has many different modes of action that directly affect the autonomic and central nervous system . The effect of ketanserin on cardiac function, for example, is very complex and ranges from its effect on cardiac muscle activity such as contraction and relaxation to its effect on the muscles of the blood vessels .

The vasoconstrictor property of ketanserin continues to take place in the lungs and kidneys . In the musculature of the bone structure, the vasodilating property prevails. Serotonin causes a phasic change in blood pressure in the human bloodstream . Initially there is a drop in blood pressure , but after a few seconds it rises again and persistent high blood pressure develops . As an antagonist, ketanserin can counteract this very well and lowers blood pressure to a normal level in the long term.

Pharmacological action

Ketanserin is a selective and competitive serotonin antagonist. The active ingredient inhibits local symptoms caused by serotonin, such as vasoconstriction , permeability, platelet aggregation , as well as blocking and releasing all factors related to growth in the human body.

This also ensures the supply of oxygen to the blood and promotes wound circulation. The so-called endothelial cells and fibroblasts multiply considerably under the stimulating influence of ketanserin. This leads to improved wound healing , which in turn prevents infections.

Furthermore, the administration of this drug leads to a blockade of histamine receptors and the vessels are dilated . The serotonin antagonist ketanserin refers to a substance that acts directly on the receptors in the human brain. It is able to activate and influence tissue hormones and neurotransmitters such as serotonin.

Ketanserin also acts selectively, distinguishing about 20 different receptors in the brain. It is also used in the treatment of migraines , depression or anxiety , as well as in the so-called irritable bowel syndrome or as an appetite suppressant . There were different preparations with different trade names, which are now no longer available anywhere in Europe.

Medical Application & Use

Ketanserin lowers blood pressure, so it mainly acts as a so-called antihypertensive drug . However, there is no appropriate approval for this drug in Germany. In other countries, too, ketanserin is subject to significant restrictions on its use.

In practice, the substance is usually only used as a reserve for particularly critical blood pressure values. It is therefore often used for operations or poisoning during pregnancy . In Europe, ketanserin is only available in the Netherlands under the name Ketesin. All other preparations, which were initially sold in various European countries, are no longer on the market.

However, ketanserin is used in research of pharmacology . Here it is used to analyze the different mechanisms of action of medicinal products. In Switzerland, the drug is used to treat wounds in animals and is available as a gel.

Risks & side effects

Ketanserin has some risks and side effects . It may cause sensitivity reactions and allergic symptoms and should not be used in hypokalemia . There is also a possibility of side effects such as drowsiness , headache and tiredness . Weight gain and dry mouth are also common . Particularly sensitive patients often suffer from dizzy spells due to significant blood pressure fluctuations during treatment with ketanserin.

Some cases of cardiac arrhythmia and tachycardia ( palpitations ) have been reported in medical studies. So, ketanserin can be contraindicated in clinical pictures such as AV block , cardiac arrhythmia, bradycardia and tachycardia, various cardiovascular syndromes and ventricular fibrillation .

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Hello! I am Lisa Newlon, and I am a medical writer and researcher with over 10 years of experience in the healthcare industry. I have a Master’s degree in Medicine, and my deep understanding of medical terminology, practices, and procedures has made me a trusted source of information in the medical world.