Active Ingredients

Enoxacin – Effect, Application & Risks

Enoxacin

Enoxacin is a medicinal substance that is widely used as a synthetic antibiotic . It is used in medicines to treat infections caused by enoxacin-sensitive bacteria . These include acute and moderate urinary tract infections , gonorrhea , skin and respiratory infections .

What is Enoxacin?

Enoxacin is a synthetically produced antibiotic. Due to its chemical and pharmacological properties and its mode of action, the substance is assigned to the group of fluoroquinolones . Also part of this group are the drugs norfloxacin and ofloxacin .

Enoxacin is one of the more modern representatives of this group. Accordingly, the drug has a particularly high level of effectiveness, which is reflected in a wide range of applications. In particular, gram-negative bacteria can be treated with enoxacin, which is not the case with all fluoroquinolones. All infectious bacteria that stain red when a differential staining procedure is performed are gram negative. This staining distinguishes them from gram-positive pathogens, which turn blue in the course of the differential staining.

The action of enoxacin is bactericidal. The antibiotic specifically kills bacteria by inhibiting their enzyme gyrase. Enoxacin is therefore also categorized as a gyrase inhibitor. The white to off-white substance is described in chemistry by the empirical formula C 15 – H 17 – F – N 4 – O 3 and has a moral mass of 320.32 g/mol. It is usually taken orally.

Pharmacological action

Enoxacin has a bactericidal effect. The drug kills infectious bacteria in a targeted manner. This is made possible by inhibiting the bacteria’s own enzyme gyrase. The enzyme is of immense importance for the cell, since it controls, among other things, the so-called DNA supercoilling (spatial arrangement of the DNA through the formation of ring-shaped molecules). Once gyrase has been inhibited, the infectious bacteria are no longer able to multiply. they are dying.

Although enoxacin is generally considered to be quite effective and has a broad spectrum of activity, it cannot be used against all bacteria. The effectiveness is particularly low against bacteria of the supercategory cocci , which include the known pathogens streptococci , pneumococci and staphylococci .

In addition, enoxacin has lost importance in recent years, since new representatives of the same drug class (e.g. levofloxacin or ciprofloxacin ) develop a more intensive pharmacological effect. Compared to enoxacin, these have a lower interaction potential and a stronger bactericidal effect.

Enoxacin is taken orally and sold in the form of film-coated tablets. Preparations that contain the active ingredient require a prescription and are available from pharmacies, i.e. only available on prescription.

Medical Application & Use

Enoxacin is used for infections caused by enoxacin-sensitive bacteria. These include some gram-negative bacteria. A medical indication of enoxacin is, among other things, infections of the urinary tract , kidneys or the prostate . In addition, enoxacin is prescribed for gonorrhea (colloquially known as “clap”). But the active ingredient is also administered for bacterial infections of the upper and lower respiratory tract, including the ear, nose and throat area.

Due to its low effectiveness, there is no indication for infections caused by pneumococci, streptococci or staphylococci. Since most pneumonia acquired outside of hospitals is caused by pneumococci, enoxacin is not usually prescribed.

However, in the case of skin infections or skin appendages, enoxacin is used without restrictions. The dosage of enoxacin-containing preparations varies depending on the disease to be controlled. Usually, however, two to four tablets are taken daily, which are prescribed for a period of seven to 14 days. In order to protect the stomach , it should be taken with or shortly after a meal.

Risks & side effects

Enoxacin must not be administered if there is hypersensitivity to the active substance. For safety reasons, the drug should also not be taken in the case of allergies to other members of the fluoroquinolone group (e.g. norfloxacin, levofloxacin, ciprofloxacin or ofloxacin).

A contraindication (medical contraindication) also exists for children and adolescents in the growth phase . In this group, there are no sufficiently reliable findings with regard to the safety of use. There is also a contraindication for epileptics and patients with a creatinine clearance below 30 ml/min.

Undesirable side effects can occur during treatment with enoxacin. Their statistical distribution looks like this:

Lisa Newlon
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Hello! I am Lisa Newlon, and I am a medical writer and researcher with over 10 years of experience in the healthcare industry. I have a Master’s degree in Medicine, and my deep understanding of medical terminology, practices, and procedures has made me a trusted source of information in the medical world.