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Ceftazidime – Effect, Application & Risks

Ceftazidime

Ceftazidime belongs to the drug group of antibiotics . The drug is part of the third-generation cephalosporins .

What is Ceftazidime?

Ceftazidime, also known as ceftazidine , is an antibiotic. It comes from the third generation of cephalosporins, which in turn belong to the beta-lactam antibiotics, and is used to treat acute and chronic infections .

The antibiotic prevents the bacteria from building up an intact cell wall and ensures that the wall becomes permeable. In this way, the drug stimulates the death of harmful bacteria.

Pharmacological action

The basis of the effect of ceftazidime is the disruption of the cell wall synthesis of the bacteria. As a result, the germs are no longer able to build an intact cell wall. This in turn causes the permeability of the cell wall and subsequently causes the disease-causing bacteria to die off.In this process, ceftazidime attaches to special proteins inside cells. Penicillins can also bind to these . Similar to the cephalosporin cefotaxime , ceftazidime is effective against gram-negative bacteria across a broad front. In addition, the antibiotic is effective against the pathogens Pseudomonas aeruginosa and Burkholderia pseudomallei . The latter is responsible for the tropical disease melioidosis (pseudo-snot). However, in contrast to cefotaxime, ceftazidime has a weaker effect against gram-positive bacteria. Thus, its positive effects on streptococci and staphylococci are limited.

Ceftazidime works in powder form. This is given to the patient by injection or infusion . The bioavailability of ceftazidime is around 91 percent. In the blood , ten percent of the antibiotic binds to plasma proteins . The plasma half-life averages 90 percent. 90 to 96 percent of the excretion of ceftazidime from the human body takes place via the kidneys .

Medical Application & Use

Ceftazidime can be used against a variety of bacterial infections . These include, above all , pneumonia that occurs in a hospital. Other possible indications are bacterial meningitis ( meningitis ), cystic fibrosis , chronic middle ear infection associated with pus formation , bone and joint infections , complicated urinary tract infections , malignant inflammation of the outer ear, and severe infections of the skin , muscles , and tendons .

Ceftazidime is also suitable for the treatment of blood poisoning (sepsis), peritonitis ( peritonitis ) after blood washing , complicated abdominal infections and fever due to a lack of neutrophilic blood cells. Ceftazidime can also be useful to prevent a urinary tract infection by surgically removing the male prostate (prostate gland) via the urethra .

In addition to adult patients and children, babies can also be treated with ceftazidime. However, since ceftazidime is only suitable for the treatment of certain pathogens, some types of infection cannot be treated with the antibiotic. The use of cephalosporins is only justified if the pathogen is classified with high probability as being sensitive to the agent.

Risks & side effects

As with other antibiotics, there is a risk of side effects associated with the use of ceftazidime . However, this does not happen in every patient. For example, allergies to these cephalosporins are much less common than after taking penicillin. Cross -allergies to penicillins are also rarely reported.In principle, ceftazidime is considered to be well tolerated. However, some people sometimes experience inflammation or blockage of blood vessels when the medicine is given by vein , and inflammation and pain when ceftazidime is injected into a muscle.

Furthermore, an excess of platelets and immature blood cells, hives-like skin rash , a lack of neutrophilic blood cells, nausea , vomiting , diarrhea , abdominal pain , headache , dizziness , itching , fever and a lack of blood platelets are possible. In rare cases there is a risk of kidney inflammation or even acute kidney failure .

Ceftazidime should not be administered if the patient is hypersensitive to the active substance or to other cephalosporins. The same applies to a previous allergic shock to penicillin, carbapenem or monobactam .

There is limited information on the effects of ceftazidime during pregnancy . No harmful effects were found in animal experiments. However, ceftazidime is only prescribed to expectant mothers if there is no other option. The preparation can be administered during breastfeeding, as there are no negative effects on the baby to be feared.

When administering ceftazidime, due to harmful interactions, care must be taken to ensure that it is not mixed with alkaline solutions with a pH above 7.5. Also, mixing ceftazidime and aminoglycoside antibiotics should be avoided. There is a risk of negative impairment of kidney function by taking these two drugs.

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Hello! I am Lisa Newlon, and I am a medical writer and researcher with over 10 years of experience in the healthcare industry. I have a Master’s degree in Medicine, and my deep understanding of medical terminology, practices, and procedures has made me a trusted source of information in the medical world.