Active Ingredients

Amisulpride – Effect, Application & Risks


The active ingredient amisulpride is a benzamide and sulpiride derivative. It is commercially available under several names and is used as an atypical neuroleptic for schizophrenia therapy. Amisulpride requires a prescription.

What is amisulpride?

The full chemical name for amisulpride is (RS)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide. Amisulpride is a dopamine receptor antagonist and is used as a so-called racemate for the treatment of acute and chronic schizophrenia. In individual cases, therapeutic successes in Tourette’s syndrome have also been observed. Amisulpride is available as 50 mg, 100 mg, 200 mg and 400 mg tablets and as a 1 ml oral solution containing 100 mg of the active substance. The doctor treating you decides on the dosage form and dose.

The neuroleptic amisulpride has an antipsychic and sedative effect. Unlike most neuroleptics, benzides such as amisulpride do not have a dampening effect, but rather a mood-enhancing and activating effect. Taking amisulpride causes fewer side effects than usual neuroleptics. In particular, phenomena such as movement disorders or fatigue occur much less frequently.

Pharmacological action

Chemically, amisulpride belongs to the group of substituted benzamides and is a derivative of sulpiride. Neuroleptics interfere with the nervous activity of the brain by changing the concentration of neurotransmitters in the brain. This influences perception and emotional life.While most of the typical neuroleptics act on the messenger substance dopamine and thus on the corresponding receptors, amisulpride, as an atypical neuroleptic, also has an inhibitory effect on other messenger substances and their binding sites in the brain. This includes serotonin .

As a drug against psychoses such as schizophrenia, the atypical neuroleptic amisulpride has a dual effect:

1. Amisulpride influences the “positive symptoms”: It dampens delusions .
2. Amisulpride also influences the “negative symptoms”: It reduces effects such as social withdrawal, isolation, reduced drive and flattened feelings in a patient.
Amisulpride therefore has an increased mood-enhancing and activating effect and is not tiring and depressant like typical neuroleptics.

The active ingredient amisulpride can interact with other centrally acting drugs and increase their effect. Amisulpride has an opposite effect on levodopa, an anti-Parkinson drug, and weakens its effect. Occasionally, an additional dose of an anti-Parkinson drug is recommended during therapy with amisulpride in order to alleviate side effects such as limited motor skills, body stiffness or cramps .

Other possible side effects of amisulpride are: tardive dyskinesia , hyperprolactinemia , menstrual disorders , impotence , loss of libido , gastrointestinal complaints, epileptic seizures , hypotension and prolongation of the QT interval of the heart. Extrapyramidal motor side effects are rare under treatment with amisulpride compared to other neuroleptics.

Medical Application & Use

Amisulprid as an atypical neuroleptic is used to treat schizophrenia and other psychoses . These are in detail:

As a non-depressant drug that lifts and activates the mood, amisulpride has a positive effect on forms of behavior such as social distrust to the point of hostility – especially towards strangers, social withdrawal, impoverished or flattened emotional life and lack of drive.

Under treatment with amisulpride, severely lethargic patients have so far been able to free themselves from the isolation they have chosen due to a lack of drive by approaching other people with interest again.

Despite an indication for acute schizophrenia, amisulpride only has limited potential here.

Risks & side effects

Amisulpride is contraindicated in certain cases – namely:

It should also be noted that amisulpride can increase the effects of other psychotropic drugs.

Children and adolescents under the age of 15 are excluded from an amisulpride prescription. It is also not recommended to be used by people aged 15 to 18 or over 65. Amisulpride should not be taken during pregnancy and lactation, and breastfeeding should be discontinued for this period.

As with other neuroleptics, a malignant neurological syndrome can occur with amisulpride. In the event of corresponding symptoms such as muscle stiffness, high fever , vegetative disorders ( pallor , sweating and circulatory instability) and clouding of consciousness, a doctor must be contacted immediately and the drug discontinued.

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Hello! I am Lisa Newlon, and I am a medical writer and researcher with over 10 years of experience in the healthcare industry. I have a Master’s degree in Medicine, and my deep understanding of medical terminology, practices, and procedures has made me a trusted source of information in the medical world.